She exclusively breastfed her infant for 6 months with no evidence of an adverse effect on milk production.Name Amphetamines Accession Number DBCAT000431 DescriptionĪnalogs or derivatives of AMPHETAMINE.
The cause of this difference was not determined.Ī mother took amphetamine 35 mg daily for narcolepsy during pregnancy and postpartum. In a retrospective Australian study, mothers who used intravenous amphetamines during pregnancy were less likely to be breastfeeding their newborn infants at discharge than mothers who abused other drugs (27% vs 42%). The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed. The authors also quoted data from another study showing that a 20 mg oral dose of dextroamphetamine produced a sustained suppression of serum prolactin by 40% in postpartum women. No assessment of milk production was presented. The 15 mg dose significantly decreased serum prolactin by 30 to 37% at times after the infusion. The 7.5 mg dose reduced serum prolactin by 25 to 32% compared to control, but the difference was not statistically significant. Eight received dextroamphetamine 7.5 mg intravenously, 6 received 15 mg intravenously and 6 who served as controls received intravenous saline. In 2 papers by the same authors, 20 women with normal physiologic hyperprolactinemia were studied on days 2 or 3 postpartum. These values represented 15%, 7% and 5% of simultaneous maternal serum concentrations. Infant serum concentrations at these times were 3.1, 2 and 1.4 mcg/L, respectively. Infant blood samples were taken just before the mother's morning amphetamine dose at 2, 5 and 9 weeks postpartum. The infant of a mother who was taking amphetamine 35 mg daily for narcolepsy during pregnancy and postpartum was exclusively breastfed for 6 months.
The infant's urinary excretion of amphetamine ranged from 0.1 to 0.3% of the mother's urinary excretion. Amphetamine was measured in a 12-hour urine collection in a breastfed infant whose mother was taking racemic amphetamine 5 mg 4 times daily. These values represent a weight-adjusted dosage of 1.9% to 2.1% of the maternal dosage and an absolute infant dosage of 11.1 to 12.4 mcg/kg daily. Breastmilk levels of amphetamine were 74, 82 and 82 mcg/L, respectively. Breastmilk samples were taken just before her morning dose at 2, 5 and 9 weeks postpartum. Milk levels were 118 and 138 mcg/L before the 2 pm doses on days 10 and 42, respectively.Ī woman took 35 mg of amphetamine daily for narcolepsy and exclusively breastfed her infant for 6 months. Trough milk levels of 55 and 68 mcg/L were found before the 10 am dose on days 10 and 42 postpartum, respectively. A nursing woman was taking racemic amphetamine 5 mg orally 4 times daily at 10 am, noon, 2 pm and 4 pm for narcolepsy.
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